Antiviral and interferon-inducing activities of a new peptidomannan, KS-2, extracted from culture mycelia of Lentinus edodes.
Identifieur interne : 002883 ( Main/Exploration ); précédent : 002882; suivant : 002884Antiviral and interferon-inducing activities of a new peptidomannan, KS-2, extracted from culture mycelia of Lentinus edodes.
Auteurs : F. Suzuki ; C. Suzuki ; E. Shimomura ; H. Maeda ; T. Fujii ; N. IshidaSource :
- The Journal of antibiotics [ 0021-8820 ] ; 1979.
Descripteurs français
- KwdFr :
- Agaricales (métabolisme), Animaux, Antiviraux, Facteurs temps, Femelle, Glycopeptides (isolement et purification), Glycopeptides (pharmacologie), Inducteurs de l'interféron, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (microbiologie), Lignées consanguines de souris, Mannanes (usage thérapeutique), Mâle, Poumon (anatomopathologie), Protéoglycanes, Souris.
- MESH :
- anatomopathologie : Infections à Orthomyxoviridae, Poumon.
- isolement et purification : Glycopeptides.
- microbiologie : Infections à Orthomyxoviridae.
- métabolisme : Agaricales.
- pharmacologie : Glycopeptides.
- usage thérapeutique : Mannanes.
- Animaux, Antiviraux, Facteurs temps, Femelle, Inducteurs de l'interféron, Infections à Orthomyxoviridae, Lignées consanguines de souris, Mâle, Protéoglycanes, Souris.
English descriptors
- KwdEn :
- Agaricales (metabolism), Animals, Antiviral Agents, Female, Glycopeptides (isolation & purification), Glycopeptides (pharmacology), Interferon Inducers, Lung (pathology), Male, Mannans (therapeutic use), Mice, Mice, Inbred Strains, Orthomyxoviridae Infections (microbiology), Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (prevention & control), Proteoglycans, Time Factors.
- MESH :
- chemical , isolation & purification : Glycopeptides.
- chemical , pharmacology : Glycopeptides.
- chemical , therapeutic use : Mannans.
- chemical : Antiviral Agents, Interferon Inducers, Proteoglycans.
- metabolism : Agaricales.
- microbiology : Orthomyxoviridae Infections.
- pathology : Lung, Orthomyxoviridae Infections.
- prevention & control : Orthomyxoviridae Infections.
- Animals, Female, Male, Mice, Mice, Inbred Strains, Time Factors.
Abstract
Oral (PO) administration of KS-2 to adult DDI mice resulted in a peak serum interferon (IF) titer of 800 units (U)/ml 20 hours after administration with detectable levels persisting until 30 hours. After intraperitoneal (IP) injection, a peak serum IF titer of 1,600 U/ml was detected and it followed the same time course as that of oral administration. The IF induced by KS-2 shared certain physico-chemical properties with the standard preparation of immune IF and was not neutralized by an antiserum against type I IF. In mice infected intranasally (IN) with influenza A2 (H2N2) virus, KS-2 was found to possess significant protective activities. Efficacy of the agent was evidenced by an increase in survivor number, a prolongation of mean survival time, an inhibition of the development of lung consolidation induced by the viral infection and a decrease in virus titer in lung tissues. Both PO and IP administrations of KS-2 protected mice against infection and significant antiviral activities were achieved not only by prophylactic but also chemotherapeutic administration. The protective activities of KS-2 against influenza virus infection in mice are discussed in view of the immunopotentiation of the host animals.
DOI: 10.7164/antibiotics.32.1336
PubMed: 575532
Affiliations:
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Le document en format XML
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Suzuki</name></author><author><name sortKey="Suzuki, C" sort="Suzuki, C" uniqKey="Suzuki C" first="C" last="Suzuki">C. Suzuki</name></author><author><name sortKey="Shimomura, E" sort="Shimomura, E" uniqKey="Shimomura E" first="E" last="Shimomura">E. Shimomura</name></author><author><name sortKey="Maeda, H" sort="Maeda, H" uniqKey="Maeda H" first="H" last="Maeda">H. Maeda</name></author><author><name sortKey="Fujii, T" sort="Fujii, T" uniqKey="Fujii T" first="T" last="Fujii">T. Fujii</name></author><author><name sortKey="Ishida, N" sort="Ishida, N" uniqKey="Ishida N" first="N" last="Ishida">N. Ishida</name></author></analytic><series><title level="j">The Journal of antibiotics</title><idno type="ISSN">0021-8820</idno><imprint><date when="1979" type="published">1979</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agaricales (metabolism)</term><term>Animals</term><term>Antiviral Agents</term><term>Female</term><term>Glycopeptides (isolation & purification)</term><term>Glycopeptides (pharmacology)</term><term>Interferon Inducers</term><term>Lung (pathology)</term><term>Male</term><term>Mannans (therapeutic use)</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Orthomyxoviridae Infections (microbiology)</term><term>Orthomyxoviridae Infections (pathology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Proteoglycans</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agaricales (métabolisme)</term><term>Animaux</term><term>Antiviraux</term><term>Facteurs temps</term><term>Femelle</term><term>Glycopeptides (isolement et purification)</term><term>Glycopeptides (pharmacologie)</term><term>Inducteurs de l'interféron</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (anatomopathologie)</term><term>Infections à Orthomyxoviridae (microbiologie)</term><term>Lignées consanguines de souris</term><term>Mannanes (usage thérapeutique)</term><term>Mâle</term><term>Poumon (anatomopathologie)</term><term>Protéoglycanes</term><term>Souris</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Glycopeptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Glycopeptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Mannans</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antiviral Agents</term><term>Interferon Inducers</term><term>Proteoglycans</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Glycopeptides</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Agaricales</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Agaricales</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Glycopeptides</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Mannanes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antiviraux</term><term>Facteurs temps</term><term>Femelle</term><term>Inducteurs de l'interféron</term><term>Infections à Orthomyxoviridae</term><term>Lignées consanguines de souris</term><term>Mâle</term><term>Protéoglycanes</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Oral (PO) administration of KS-2 to adult DDI mice resulted in a peak serum interferon (IF) titer of 800 units (U)/ml 20 hours after administration with detectable levels persisting until 30 hours. After intraperitoneal (IP) injection, a peak serum IF titer of 1,600 U/ml was detected and it followed the same time course as that of oral administration. The IF induced by KS-2 shared certain physico-chemical properties with the standard preparation of immune IF and was not neutralized by an antiserum against type I IF. In mice infected intranasally (IN) with influenza A2 (H2N2) virus, KS-2 was found to possess significant protective activities. Efficacy of the agent was evidenced by an increase in survivor number, a prolongation of mean survival time, an inhibition of the development of lung consolidation induced by the viral infection and a decrease in virus titer in lung tissues. Both PO and IP administrations of KS-2 protected mice against infection and significant antiviral activities were achieved not only by prophylactic but also chemotherapeutic administration. The protective activities of KS-2 against influenza virus infection in mice are discussed in view of the immunopotentiation of the host animals.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Fujii, T" sort="Fujii, T" uniqKey="Fujii T" first="T" last="Fujii">T. Fujii</name><name sortKey="Ishida, N" sort="Ishida, N" uniqKey="Ishida N" first="N" last="Ishida">N. Ishida</name><name sortKey="Maeda, H" sort="Maeda, H" uniqKey="Maeda H" first="H" last="Maeda">H. Maeda</name><name sortKey="Shimomura, E" sort="Shimomura, E" uniqKey="Shimomura E" first="E" last="Shimomura">E. Shimomura</name><name sortKey="Suzuki, C" sort="Suzuki, C" uniqKey="Suzuki C" first="C" last="Suzuki">C. Suzuki</name><name sortKey="Suzuki, F" sort="Suzuki, F" uniqKey="Suzuki F" first="F" last="Suzuki">F. Suzuki</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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